Cinema 4D Video Tutorial: Creating Realistic Smoke

first_imgCreate organic looking smoke effects inside Cinema 4D – no third party plugins required!Creating realistic smoke in post can be a significant challenge. Mimicking the billowing movement, modeling realistic particles, tweaking the opacity – there’s a lot to consider. Many VFX pros use JawSet’s TurbulenceFD plug-in to create realistic smoke and fire effects in Cinema4D or After Effects. TurbulenceFD is a powerhouse, but it will set you back several hundred dollars. So how do you create smoke with the native tools inside C4D ?The following video tutorial demonstrates how to create realistic smoke in Cinema 4D with only a few clicks of the mouse. It’s a lot easier than you might imagine and can be done with native Cinema 4D tools:What’s smoke without an explosion to precede it? Check out our ‘Creating Explosions in Cinema 4D‘ post to figure out how to explode objects using Cinema 4D.Have any tips for making better smoke in Cinema 4D?Let us know about it in the comments below.last_img read more

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7 Indie Filmmaking Tips for Shooting Day for Night

first_imgTip 1: Contrast Is Your Friend“One of the biggest differences between night and day,” Barber points out, “is how contrasty everything is.” By its nature, ambient daylight shooting is predominantly bright light and small parts of shadow, which is the opposite of what you’d actually see (and like to re-create) when depicting night.The difference between the light and shadow is pretty dramatic at night. So, when you’re shooting day for night, you have to be very conscious of how you’ll need to create that contrast, as it won’t occur naturally.For Barber and his crew, this meant that understanding, creating, and emphasizing contrast was paramount to their day-for-night production shoots.Tip 2: Direction of Light Is ImportantWe had the most success using backlight and sidelight for our highlights. The other piece to remember is that you can always use HMIs or bounce sunlight. In our case, we used mirrors in ultra-wide shots to get a nice rim around our actors. Which goes back to getting that contrast, which comes from the direction of light.One of the best ways to harness contrast is in Barber’s second tip: understand the importance of light direction. Barber and his crew had to find innovative ways to manipulate light direction to create backlight or sidelights for highlights, which may not have existed naturally.Tip 3: A Clean and Clear SkylineOne of the most endearing parts of Barber’s film came from the beautiful, star-filled night skies that brought out the childlike wonder in the film’s world. Creating a picturesque night-canopy, while shooting day-for-night, was no easy feat and required a post-production friendly eye.You either want zero sky in the shot, or you want a really clean skyline you can replace. For us, we were lucky because we were trying to create a Miyazaki-type world, so we wanted big, beautiful night skies with lots of expanse. So we were actually either totally framing out the sky or we would find a way where we got a nice, clean horizon line where we could completely replace the sky with something more majestic.Without a clean and consistent horizon line, the post-production masking process would have been much more difficult, Barber explained. That could have made entire scenes too time- or labor intensive to include.Tip 4: Consider Color TemperatureFor those shooting day-for-night, you’re going to probably want a violet night or a greenish night or a bluish night or a desaturated night. The way you can get there is by playing with LUTs and camera settings to get a basic idea on set of what you’ll get. We did this on our dusk-for-night shot, and we were shooting with an ARRI Alexa, which handles a lot of things well. We would do things like reduce the green or play with color levels a little bit to get a sense of something of a pre-look.If you’re new to color temperature, you can read some of our posts about color and light temperature here. As Barber’s film shows, knowing how to work with colors at the source is a huge help on tricky production days.Tip 5: Look at ExamplesImage from Pan’s Labyrinth via Warner Bros.Sometimes you’ll find a scene or two in a movie, but we wanted to see how we could make it work for an extended period. We looked at Uncle Boonmee Who Can Recall His Past Lives, but we also looked at some clips from National Geographic, which actually has some great clips, Guillermo Del Toro did some day-for-night. Basically we looked high and low for good examples.Perhaps the best way to learn about day-for-night shooting (or any production style, really) is to study the experts. Especially, as in Barber’s case, when you’re shooting a film that features a much greater amount of day-for-night than your typical production. Barber and his team put in the time from the get-go to find examples to influence their look and style.Tip 6: Know that Day-For-Night Is a LookIt works for our movie because we’re in a mystical forest and having a childlike Where The Wild Things Are–esque adventure. (Editor’s note: it also helps to have original costumes designed by the same fabricator.) Essentially, if the story is strong enough, you’ll have the audience going right along with you. It works more when you want to have a distinctive look. It’s more about your audience feeling like it’s night then convincing them that it is.If you’re looking for one piece of advice to take away from this article, please let this be it. As Barber stresses, the goal of INTO THE WHO KNOWS! (or any production, for that matter) is not to create a scene that looks like night during the day. It’s to create a look that can exist inside a world where the audience can feel like it is night.Tip 7: Hire a Great DP and a Great ColoristBarber’s production would be for naught without the tireless work of a creative and dutiful production crew and post-production colorist.Probably the most important tip. Our DP Patrick Smith and our colorist Anand Modi were excellent and really knew their stuff, and also were not afraid to experiment. Our colorist, for example, worked with lots of technical tricks like working with black levels and dealing with contrast, and just setting colors into the right place to bring these different shots together.You can check out the film’s trailer below or read more about their premiere at the Dallas International Film Festival here. Be sure to follow their Facebook and website for updates on screenings and where to find the film online. These real-world indie filmmaking production tips from Micah Barber will improve your next day-for-night shoot.All images via INTO THE WHO KNOWS! and DIFF.We chatted with filmmaker Micah Barber at the premiere of his film INTO THE WHO KNOWS! at the Dallas International Film Festival about his project and some innovative tips for shooting day-for-night scenes.Micah Barber (4th from left) with the cast of INTO THE WHO KNOWS! at the world premiere at DIFF 2017.Barber’s debut film, INTO THE WHO KNOWS!, is a kids’ adventure movie, which can be a rare film festival find these days. Produced by Alexandra Malick (the wife of famed filmmaker Terrence Malick), the film follows ten-year-old Thomas (Bryce Gheisar) on a whimsical Calvin and Hobbes-esque journey full of adventure and wonder.As such, Barber and his crew were out in the woods and forced to work a tight schedule that included many day-for-night and dusk-for-night shoots. For those looking for a few day-for-night tips, here are Barber’s seven indie filmmaking insights. Have any tips or tricks for shooting day-for-night of your own? Let us know in the comments.last_img read more

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Creating an Interconnected Icon Tree in After Effects + 30 Free Icons

first_imgLearn how to make an interconnected icon tree using 30 FREE animated icons in After Effects.To build an interconnected icon tree, you first need some icons. You may choose to draw and animate your own, but in this tutorial, we’re using the excellent Technicons freebie pack from RocketStock.GET 30 FREE ANIMATED ICONS FROM ROCKETSTOCKAfter you’ve downloaded or created your icons, import them into your AE project.We will also be using a script called Connect Layers from Motion Boutique. It is available here at pay-what-you-want pricing. The script does a lot of math that connects layers with shape layer lines.Now that you have all your assets, let’s get started. Make Individual Icon CompsEach icon should have its own composition. Start by dragging the first icon you intend to use onto the new composition icon in the project panel. This will create a composition the exact size, duration, and frame rate of the source files.Inside the new composition, we will use the Time Stretch to speed up the .mov file.Select the layer, and in the top menus, go to Layer > Time > Time stretch. Enter a value of 50 to double the speed.With the .mov layer shortened, we want to trim the composition to that new layer’s length. Set the playhead at the end of the layer, and hit “n” to set the work area’s end at that point, and then trim the composition to fit the new work area.This container is also where we want to add a background circle for our icon to sit on, to separate it from the background. Make an ellipse by double-clicking on the shape layer ellipse with no layers selected (otherwise you’ll make a mask or shape on an existing layer).Twirl into the contents and ellipse parameters to access the ellipse size. Set keyframes at 0 frames and 20 frames for [0,0] and [350,350] respectively, and adjust the value graph in the graph editor as you see below to achieve a popping-on look. Don’t worry that the circle goes beyond the outside of the composition.If you’re only making a network of one type of icon, then you’re done. But otherwise, you will need icon comps with different contents. First, rename your composition something you will remember, then duplicate it.Open the duplicate and swap out the source of the .mov for another by selecting the layer to replace, holding alt, and dragging from the project window. Then rename the composition and repeat as necessary.Putting It TogetherCreate a new composition that is the same frame rate as your earlier comps — for us that’s 29.97. This is the composition where everything will come together.Drag out your first icon to the timeline and adjust where in time you want the animation to start. We want the icons to shift and drift on their own in their cloud, so we will use expressions to automate their movement. Apply the following expressions by holding alt and clicking the stopwatch to the position:wiggle(.1,100)and scale:x=wiggle(.1,10)[0];[x,x]Now we can position and scale the layers as we like, and they will still have some variance over time. Set the scale values to roughly 60%.Duplicate the first icon, and replace it using the previous method of holding alt and dragging in another comps. Continue this until you have all the icons you would like to connect.Connecting the NetworkWith your icons out on the timeline, you can now connect them with the connect layers script. Select the layers you want to connect to each other.Then run the script from the File > Scripts > Run Script file, and select the Connect Layers file you’ve downloaded previously. This will open a dialogue window with options. This will present you three modes of connecting layers. If you have only a few icons you want to connect, I recommend the tree method. Or you can use the triangulation method and delete the piece you don’t need.This will create many rectangles that are pointing from one layer to another. To animate and format the layers, twirl into the content and twirl into the stroke. Increase the stroke thickness as necessary and change the line cap and joint to round. To animate the stroke, we will use the trim paths setting keyframes on the end of the existing trim paths from 0 to 50%. Since the “line” is made of a rectangle, we only need to stroke half of the shape.If the line is animating in the wrong direction, adjust the offset to 180 degrees. Ease the trim path keyframes for smoother motion. The animation of each line may vary by length, but they should be around 10 frames.Finally, time up the lines so they emanate from an icon after it has animated on completely. The icon the line is animating to should begin animating one or two frames before the line has completed its animation.Finishing UpTo pack up the network for an easy transition, you can set keyframes on the position of all the icons so they move to the middle of the frame. Set position keyframes to end, in this case, at 960,540. As the icons are moving to the middle, have the middlemost icon (presumably the most central of the network, and the topmost layer) scale up to cover the incoming icons.At the apex of the scale, trim all the other layers to end. Then set the last remaining icon scale to zero. Adjust the keyframes in the graph editor, and set to speed graph as you see below to get a nice swell and quick out for the piece.last_img read more

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When To Take Your Team Off the Field (A Note to the Sales Leader)

first_imgWhen you take your team off the field make sure it is achieve the right outcomes.Too often sales organizations take their sales teams off the field to accomplish things that are better accomplished some other way. They take them off the field to cover administrative or compliance issues. And they’re important issues, too. But this kind of information transfer isn’t normally of a high enough value to make it worthwhile–even when you cover a lot of issues.The best reason to take your sales team off the field is to improve their ability to sell, not to cover administrative issues. The goal is to put them back on the field better prepared to play the game and win.Take Them Off the Field for TrainingTake them off the field for training. Taking your team off the field to train them returns them to the field with new beliefs, new skills, and new ideas about how to succeed and win business. It’s an investment in better sales outcomes. The return on invested of time is greater than time invested in administrative and compliance issues.Take Them Off the Field for CoachingTake them off the field for individual and group coaching. There isn’t a better or more effective use of than coaching, especially individual coaching. Whether the coaching is for personal improvement, coaching the pipeline, coaching opportunities, or coaching time management, it’s the very best reason to take a salesperson off the field. It has the greatest direct impact on results.It can often feel like you’re being productive by using the time you have with your sales force to cover everything you need–or want–to cover. But time taken away from improving the sales force’s ability is time that isn’t easily recovered. Ask yourself if the administrative and compliance stuff can’t be better handled in some other medium.QuestionsHow often do you take your sales team off the field?When you take your sales team off the field, what are the main outcomes you need to achieve?How much time is devoted to administrative issues?Is there an equally effective way to disseminate that information that doesn’t require your seeing the whites of their eyes? Essential Reading! Get my 2nd book: The Lost Art of Closing “In The Lost Art of Closing, Anthony proves that the final commitment can actually be one of the easiest parts of the sales process—if you’ve set it up properly with other commitments that have to happen long before the close. The key is to lead customers through a series of necessary steps designed to prevent a purchase stall.” Buy Nowlast_img read more

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Three Must Have Reports from Your Sales Force Automation

first_imgThis post was written as part of the IBM for Midsize Business program, which provides midsize businesses with the tools, expertise and solutions they need to become engines of a smarter planet.There are three reports a sales manager must be able to obtain from their sales force automation or customer relationship software. Without these reports, the sales manager is flying blind. Let’s look at each of them.New Opportunity AcquisitionFirst, a sales manager must have a view of the new opportunities their team is generating. I call this report a New Opportunity Acquisition report.Any sales manager who is honest about where they place their focus and attention will admit that is often given to sales opportunities at the end of the sales process. There is so much pressure to make the number, they want to know which opportunities their team can close and by what date.But no opportunity is closed that is not first opened. One of the primary challenges sales organizations and sales people now face is opportunity acquisition. By putting opportunity acquisition first, you are telling your salespeople what you value most. More opportunities equals more opportunities to win. It also means that the sales manager has fewer “must win” opportunities.Pipeline with Days in StageSecond, the sales manager needs a view of their pipeline that includes the days each opportunity has lived in that particular stage.I once worked with a client who believed they had a very large pipeline, one that was more than enough to cover the number they needed to make. I asked them to run two reports for me. The first report showed the days each opportunity had lived in that particular stage. The second report removed any opportunity that had lived in a stage twice as long as the average time of this company’s won opportunities. This cut their pipeline by 80%. It was a massive reality check.By monitoring the time it takes an opportunity to flow through the process, you uncover stuck deals. As an opportunity starts to age past the time an opportunity normally lives in that stage, you can test the opportunity to see if it is stalled. If it is, you can help the salesperson troubleshoot the opportunity and get it back on track.But that isn’t the only troubleshooting you can do. Days in Stage can also help you uncover problems with the sales process. Every good sales process should have an expiration date, a date when you review it to make sure it’s still valid. If opportunities sit on stage too long, maybe something has changed. Maybe your prospective clients need something different from you. If you see a pattern, it’s worth investing to decide if you need to make changes.Finally, Days in Stage can also uncover the sales force’s development needs. If the sales force struggles getting past a certain point in the sales process, they may have an underlying developmental need. As an example, if an opportunity sits in the acquisition stage too long, it may indicate that salesperson didn’t acquire the of the stakeholders early enough in the process.Days in stage is a crucial report for diagnosing sales process problems and moving stuck deals.Client CommitmentsThe final report is client commitments. Opportunities don’t walk themselves from target to close. That path is really a number of commitments that the prospective client agrees to take with the salesperson. It’s a linking together of these commitments.Whether the report you review is the salesperson’s calendared commitments the client has agreed to take or activities, it’s critical to capture and review these commitments.All activity isn’t created equal. The highest value activity for a salesperson is most often the time they spend face-to-face with their clients. Reviewing their calendared commitments provides the sales manager with the opportunity to review the salesperson’s plan and their deal strategy. It allows the sales manager to ensure that the salesperson has everything they need to create value for the client during these interactions. Effective activity beats activity alone every time. This is how you ensure effective activity.There are hundreds of reports you might pull from your customer relationship or sales force automation software. These three are critical management tools that can help you and your team sell better—and faster. Get the Free eBook! Learn how to sell without a sales manager. Download my free eBook! You need to make sales. You need help now. We’ve got you covered. This eBook will help you Seize Your Sales Destiny, with or without a manager. Download Nowlast_img read more

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Transactional Selling to Avoid Conflicts Around Price

first_img Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Now The reason so many people want to be transactional and agree to a discount their price is that it eliminates one of the major areas of conflict in sales. If you agree to your prospective client’s price, then there is no conflict, you just say “yes” and you are off to the races.While this approach eliminates a natural conflict that occurs in most major deals, it eliminates a lot more than that.What You Are LosingBeing transactional eliminates any perception that you are a consultative salesperson or trusted advisor. A trusted advisor engages in the difficult conversation. They don’t fear it. Instead, they embrace it, knowing that they are demonstrating their value by tackling the difficult stuff many salespeople fear.When you are transactional and competing on price, you eliminate the ability to differentiate your offering. You eliminate the perception of value. Price is an expression of value. The low price leaders in your space don’t compete on value. Lowest price is an absence of value. When you are transactional and reduce your price, you are projecting a lack of value and a lack of differentiation.Being transactional, especially when it comes to pricing, eliminates the profit you need to execute the solution that you are selling your client. It eliminates the likelihood that you succeed for your client and, over time, it eliminates the possibility of retaining them as your client.Know Pain, Know GainBy engaging in the back and forth of a negotiation around price, you deal with the inherent conflict. You also gain the opportunity to turn a sometimes uncomfortable conversation into a collaboration around making the right investments, producing the right results, and choosing the right partner.This conversation around price provides you with the opportunity to move from transactional to strategic partner—but only if you are willing to engage in what can sometimes feel like conflict.QuestionsHave you ever been tempted to reduce your price to avoid a conflict (or a difficult conversation)?What do you risk losing by behaving transactionally, especially when it comes to price?What do you gain by taking business at a markup that doesn’t serve your needs and puts your results at risk?How do you turn a difficult conversation that is a natural conflict into a collaboration?last_img read more

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The Hustler’s Playbook: Be Indispensable

first_imgA hustler never fails to produce the necessary result, regardless of what that result might be this time. You can count on them to get done what needs to be done.A hustler takes initiative and does what need to be done proactively, before it is necessary. She is resourceful enough to find a way where none presently exists. You can count on the hustler to come up with something that works.The hustler cares more than anyone else would dare. She is unafraid to admit that she drank the Kool-Aid, that she shares her company’s cultural beliefs, and that who they are matters. She is not a cynic. Nor does she bitch or whine.The hustler goes first. If it’s a nasty, unpleasant, or difficult task, the hustler volunteers to take it. He wades in before anyone else. No one ever has to ask. The hustler just does it.The hustler isn’t a glory hound. Hustling isn’t about the accolades or awards. The hustler’s identity and life’s meaning run much deeper than that. Success is at the core of who the hustler is, with or without the press clips.You can get by without those who fail to produce results because they don’t put forth the effort. You can get by without those reactive souls who only move when some outside force acts upon them. You can live without the many who refuse to exercise their resourcefulness and their creativity and apply these greatest of human attributes to the challenge at hand. You can certainly live without the cynic and his negativity.When all the dust settles, the hustler is the last one standing. The hustler is indispensable. Essential Reading! Get my first book: The Only Sale Guide You’ll Ever Need “The USA Today bestseller by the star sales speaker and author of The Sales Blog that reveals how all salespeople can attain huge sales success through strategies backed by extensive research and experience.” Buy Nowlast_img read more

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Focus Is the New Currency of Success

first_imgThe new currency of success is focus and attention. If you want greater results, focus. If want to succeed with greater certainty—and faster—focus.What Has Your Attention?The starting point of improving any area of your life is to bring attention to that area. If you want to know how you spend your time, take an inventory. Track what you do for a couple of days and you will learn a lot about yourself, much of it, you may not like. You will, however, find room for improvement.You can do the same thing with your focus. What do you focus on? What gets your attention? Does what you pay attention to really deserve your attention?How much of your focus do you give to external events and circumstances as a way to explain why you aren’t producing the results you need?How much of your focus goes to things that are wholly outside of your control and influence?Is it easy for you to find yourself in the browser or in the inbox having focused on trivialities while ignoring your priorities?Unaddressed and UncompletedWithout focus, your most important priorities sit unaddressed and uncompleted. It’s easy to trade the small and meaningless for the big and important without ever meaning to make that choice.Focus means the browser is closed. It means your email inbox is closed. Your notifications are turned off. You have blocked out distractions so you can give what’s most important your full and undivided attention.How much of your focus do you give to the things that produce the results you want in spite of anything outside of you?How much of your focus do you give to the things you can control or influence?How often do you focus all of your attention on a single task without any opportunity to be distracted?If your tasks are never completed, it’s a lack of focus. If you make little progress on your priorities, it’s because you haven’t given them your full attention. If your thoughts are elsewhere, you cannot produce the results you are capable of producing.Your focus is power concentrated. It allows you to produce better work. Your focus produces those results faster, too.Pay attention to what has your attention.last_img read more

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Overcoming Toxic Culture Through Mastering Civility, with Christine Porath – Episode #99

first_imgPodcast: Play in new window | Download (Duration: 32:11 — 25.9MB)Subscribe: Apple Podcasts | Android | Email | Google Podcasts | RSSIt should not come as a surprise that some of the most important things in life are the most basic. Civility is one of those things that is essential to maintaining and building great relationships with others but is often cast aside for the sake of attaining goals at the expense of those relationships. In this conversation, Anthony talks with Christine Porath, author of the new book “Mastering Civility.” Her insights into the human condition and the things that drive us to be not only uncivil but downright petty reveal the foundational things that we need to come to grips with in order to begin building healthy company cultures rather than toxic ones.Overcoming Toxic Culture Through Mastering Civility, with Christine Porath – Episode #99Click To TweetThe fundamentals of civility are so basic but also so seldom doneNo one would argue against civility being one of the foundational practices that undergird healthy human relationships. Yet, it is one of the things that is most quickly cast aside when it comes to dealing with others in hierarchical structures like companies and chains of command. Christine Porath is convinced that a return to civility will enable toxic cultures to be made healthy and poor performing teams be made into record-breakers. This conversation is full of insight so be sure you take the time to listen.Learning to listen is one of the best ways to chip away at a toxic cultureAll of us have a cell phone. We leave it sitting on the desk during meetings and we even take it to the bathroom with us. We think of it as a tool but it often becomes a distraction that keeps us from truly listening to the people we meet face-to-face every day. Christine Porath points out how new habits – like removing our cell phone from the desk – can help us listen in ways that begin to chip away at the toxic cultures within our companies and organizations. Find out how Kristine suggest we go about making these kinds of fundamental changes, on this episode of in the arena.Learning to listen is one of the best ways to chip away at a toxic culture @PorathCClick To TweetConnection has to come first before effective leadership can happenEffective leadership is a goal for most CEOs and managers, but it can seem very elusive and difficult to attain. Christine Porath says that effective leadership hinges on personal connection much more than it does leadership techniques or principles. Her conviction is that those who learn to connect with the people they lead will be much more effective in their leadership, and research is bearing out that conviction. Christine shares basic steps toward greater connection with the people around us in this conversation with Anthony.Why we don’t give others the benefit of the doubt but always give ourselves the benefit of the doubtYou may or may not have noticed it, but one of the behaviors that almost every human being is guilty of is giving the benefit of the doubt to ourselves but not giving the benefit of the doubt to others. At the tail end of this conversation, Anthony and his guest, Christine Porath talk about how to overcome the unconscious stereotypes and judgments we make about people without knowing all the facts, and the benefits that a “benefit of the doubt” mindset can have in building a company culture that is sympathetic and supportive of the people in it.Why we don’t give others the benefit of the doubt but always give ourselves the benefit of the doubt @PorathCClick To TweetOutline of this great episode Why Anthony invited Christine to be on the show to talk about her book, “Mastering Civility” The personal experiences that pushed Christine to write about civility What makes for a toxic work environment and what impact does it have? Everyone is watching the leader to know how to behave within the organization The fundamentals of civility that are basic, but not done How warmth and competence are foundational to leading people Judge not: What it means to overcome your own biases and how it increases civility Why we assume people do not have good intention and what we should do insteadResources & Links mentioned in this episodewww.ChristinePorath.com – Christine’s website – take your own civility quizChristine’s book: Mastering CivilityBOOK: The Cost of Bad BehaviorReWorkGoogle’s research on psychological safetyThe theme song “Into the Arena” is written and produced by Chris Sernel. You can find it on SoundcloudConnect with AnthonyWebsite: www.TheSalesBlog.comYoutube: www.Youtube.com/IannarinoFacebook: https://www.facebook.com/iannarinoTwitter: https://twitter.com/iannarinoGoogle Plus: https://plus.google.com/+SAnthonyIannarinoLinkedIn: https://www.linkedin.com/in/iannarino Tweets you can use to share this episodeThe fundamentals of civility are so basic but also so seldom done @PorathCClick To TweetConnection has to come first before effective leadership can happen @PorathCClick To TweetSubscribe toIn the ArenaApple PodcastsGoogle PodcastsAndroidby EmailRSSOr subscribe with your favorite app by using the address below Get the Free eBook! Learn how to sell without a sales manager. Download my free eBook! You need to make sales. You need help now. We’ve got you covered. This eBook will help you Seize Your Sales Destiny, with or without a manager. Download Nowlast_img read more

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Trust and Integrity Are the Currencies in Which You Trade

first_imgA young salesperson reached out to offer me a favor. He wanted to use his company’s technology to take the list of OutBound 18’ attendees and provide me with insights about each of them before the conference. I rejected his request because I would not betray the trust of the people on the attendee list by giving their information to anyone other than the sponsors. I also had a sense that something was amiss.The young salesperson persisted, tried again, this time sharing the truth. He explained that his company was new and that his CEO had charged with him finding a way to get the attendee list so that they could schedule meetings with the attendees at the event. They believed that their product would benefit the attendees by helping them with outbound sales efforts. The approach the salesperson and his CEO took was a “whatever it takes “attitude, the kind that doesn’t recognize the truth that trust and integrity are the currency in which you trade.I emailed the young salesperson to caution him about his approach. He replied that he was hustling and that as someone who also pushes to build businesses, I must understand. In this, he was off the mark by the very widest of margins.I shared this story with my friend, Jeb Blount, and he confirmed that the company tried to buy a sponsorship but weren’t able to invest. Hearing this from Jeb made a bad story every worse.The story here is a cautionary tale. Had I been duped into providing this non-sponsor the list of attendees, not only would I have betrayed the trust of the attendees, but I would have also created a problem for the sponsors, who invested in the event. His lack of integrity would have become my lack of integrity.There are too many lessons here to recount them all, but let me share a few.There is never a reason to operate from a “whatever it takes” mindset if that idea allows you to do anything that subtracts from trust or throws your character into doubt. Whatever it takes is the mantra of those who are selfish and self-oriented and lack skillful means to get what they want and maintain their integrity.If you allow yourself to become desperate and start looking for the “easy way,” the choice you make to try to avoid the work is probably one that causes you to do things that make you untrustworthy. You protect yourself from ever finding yourself in this situation by not putting yourself in situations where you are desperate.You are better off suffering any negative consequences that come with failing if you leave with your character intact. Once you have established yourself as someone of low character and a willingness to lie to get what you want, you will have a tough time creating relationships.A thief is always a thief, no matter how pleasant they may appear to be. A liar is a liar, even if they are charming, and even when they believe that they are lying for what they think to be a worthy cause.last_img read more

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Hold These Constant

first_img Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Now This is an age of constant, accelerating, disruptive change, much of it providing an improvement, but as much causing damage the extent of which won’t be clear until some time later. When the world seems to be spinning ever faster, there are constants that can give you some mooring.Integrity: Be exactly who you say you are, and act in accordance therewith. No matter what changes, this must not, as it has been required of those who have known success through the ages.Improvement: There aren’t too many things you might do that will serve you as well as improving yourself, but especially when things seem to be changing most. The fact that you are engaged in learning ups your odds of success.Abundance: The world is split into two groups of people, those who see scarcity and those who see abundance. The world will look very much like what you imagine, and abundance is the better choice.Grateful: Those who are grateful for what they have often find that more good things come to them, and those who are not appreciative find very little comes to them.Resourcefulness: In a world where answers aren’t easy, the ability to be creative and generate ideas is an advantage. You already possess unlimited creativity, but you have to use it.Initiative: Waiting is not a strategy for success in any time, but least of all when change is occurring all around you. Keep moving, even if it requires you to change course.Progress: Small steps in the right direction are more likely than a miraculous transformation or a hit on your first try. The right direction is the goal, not perfection.These attributes, these character-traits, will provide you a platform on which to stand while the world spins around you.last_img read more

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Sanitation workers in Faridabad shed cloths to get jobs back

first_imgNearly 160 semi-naked sanitation workers, who were rendered “jobless” after the HUDA handed over maintenance of certain sectors to the municipal corporation, carried out a protest march here demanding restoration of their jobs.The protest march on Wednesday started outside the municipal corporation office and culminated at city’s Neelam Chowk during which the workers raised slogans against the government and the administration.The Haryana Urban Development Authority (HUDA) had a few months ago handed over the maintenance of certain sectors and markets to the municipal corporation.These 160 workers, however, were assured of being “adjusted” in the municipal corporation, claimed Naresh Kumar Shastri, who led the protest which was held yesterday.He said on July 11, Principal Secretary Haryana, R K Khullar had directed the corporation, Faridabad, that these HUDA employees be taken on duty with immediate effect.“The government has agreed to include 160 workers in the Faridabad Municipal Corporation. Official orders have been given but the implementation is getting delayed,” he claimed, alleging civic body officials were delaying the process.“Names of our children have been struck off school registers because we are unable to pay their fees. We are unable to pay electricity bills and landlords are asking us to vacate houses,” Shastri added.The workers said if their jobs are not restored, they will launch a protest on August 9 carrying “begging bowls” in their hands.last_img read more

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Sushil Modi trades charges with Tejashwi

first_imgSlamming Leader of the Opposition in the Bihar Assembly Tejashwi Yadav for possessing property worth over ₹3 crore in Patna, which was recently attached by the Income Tax Department, Deputy Chief Minister Sushil Kumar Modi on Saturday asked him to publicly explain how he came to own such a large property in the State capital. Mr. Yadav said in response that Mr. Sushil Modi was in the habit of making frivolous allegations against his family but “never turns up for one-on-one discussions”.Mr. Modi told journalists in Patna, “Tejashwi Yadav purchased the building on a 7,105 sq ft plot, priced at over ₹3.5 core at that time, through a shell company, Fairgrow Holdings, registered at a fake address in Kolkata. It is the same property that the I-T Department has been trying to find for the last year.”“Tejashwi [Yadav] should explain when the land was purchased and who owns this land and the house. He should also explain whose black money was invested in Fairgrow Holdings, which was not operational. He should also disclose what connection this house had with animal husbandry scam accused R. K. Rana.”Mr. Modi said that he, too, had stated in June 2017 that former Chief Minister Lalu Prasad’s family had purchased a large house in the State capital, but it was not detected at the time because the purchase was made through a shell company.last_img read more

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Prayer should be offered in mosques instead of public places, Haryana CM Manohar Lal Khattar

first_imgFollowing instances of disruption while namaz (prayer) was being offered in open spaces in the National Capital Region over the past few days, Haryana Chief Minister Manohar Lal Khattar said on Sunday that it should be offered in mosques or ‘eidgahs’ instead of public places.“We are of the view that namaz should be offered at mosques or ‘eidgahs’… In case of shortage of space, it should be offered at a personal place. These are issues which should not be put for public display… It should be avoided at public places for the convenience of all,” he told journalists here.Mr. Khattar said directions had been issued to officials to take precautionary measures to ensure harmony. Some organisations had submitted complaints regarding namaz at public places, he added.Mr. Khattar said his government ensured law and order in the State so that the people could live peacefully. “…no criminal can escape after committing any crime.”The Chief Minister said Haryana Police Cadet Corps, on the lines of the National Cadet Corps, was being set up, involving students from Class XI to graduation.Mr. Khattar urged the Punjab government to join hands with Haryana to check wasteful flow of Ravi waters to Pakistan because of the unprecedented water crisis looming in both States.“I have written to Punjab Chief Minister Capt. Amarinder Singh to direct the officers concerned to take up the proposal in right earnest. Quoting from the letter, he said: “More and more blocks of Haryana and Punjab have anyway been slipping into the category of over-exploited blocks even as our hard-working farmers toil in the face of a stressed farm sector. I think the time has come when we must join hands in checking the wasteful flow of Ravi waters to Pakistan.”Khattar’s statementIn a late evening statement, Haryana Chief Minister Manohar Lal Khattar clarified that in his statement regarding offering Namaz at public places, he had never said anything regarding stopping anyone from offering Namaz.He said if anyone had any problem regarding offering Namaz at public places, he/she could inform the administration and the police. “It is the responsibility of the administration and police to maintain law and order and the state government is bound to maintain peace,” he added.PTI adds:Hindutva organisations have been trying to stop Friday prayers in Gurgaon over the last two weeks alleging that some people were trying to grab land in a bid to merge it with a mosque. There were disruptions caused at Wazirabad, Atul Kataria Chowk, Cyber Park, Bakhtawar Chowk and at South City, the police said.last_img read more

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17 killed in J&K bus accident

first_imgAt least 17 passengers were killed and 16 more injured when a mini bus skidded off the road and plunged into a gorge in Jammu and Kashmir’s Kishtwar district on September 14, officials said. The accident occurred at Dandaran, near Thakrai, when the driver of the mini bus, which was on its way to Kishtwar from the Keshwan area, lost control of it and the vehicle plunged into the over-300-foot gorge, near the Chenab riverbed, on September 14 morning, they said.“A total of 17 persons died and 16 others injured in the unfortunate incident,” District Development Commissioner (Kishtwar) Angrez Singh Rana told PTI. He said the dead included three women and the driver of the ill-fated vehicle Ashraf Hussain.Interestingly, Hussain was fined by the traffic police the day before for overloading, officials said.Mr. Rana said most of the victims died on the spot. One of the 11 critically injured persons, airlifted to Jammu for specialised treatment, was declared brought dead by doctors at the Government Medical College Hospital, Jammu.Officials said the bus was carrying over 30 passengers. They said five of the injured were undergoing treatment at a local hospital and their condition was stated to be “stable”. This is the third major accident in Kishtwar district in the last one month.While 13 Machail Yatra devotees were killed when their cab plunged into a gorge on August 21, seven persons were killed and 12 others injured when two vehicles were hit by boulders a day earlier.last_img read more

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BSF soldier injures two, kills self in Tripura camp

first_imgA soldier of the Border Security Force (BSF) sprayed bullets at his colleagues in a camp in Tripura on Friday night and wounded two of them. He later shot himself with his service weapon.BSF officers refused to disclose details of the incident. Arun Kumar Verma, a senior officer of the BSF Tripura Frontier, said on Saturday that a probe was ordered. He said constable P.D. Rao who opened fire in the camp died.last_img

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Setback for Kumar in Saradha scam case

first_imgIn a setback for former Kolkata Police Commissioner Rajeev Kumar, the Supreme Court Registry on Tuesday informed him that his urgent plea to extend his protection from arrest in connection with the Saradha ponzi scam case would not be heard this week.Mr. Kumar was granted seven days’ protection, from May 17 onwards, to facilitate him to seek any legal relief, including anticipatory bail. But he had returned to the apex court on May 20 with an urgent application for an indefinite extension of protection. Lawyers’ strikeHe had said the courts in West Bengal were not functioning due to a lawyers’ strike and he was unable to approach any for legal relief. He had sought the apex court to provide him with indefinite protection from any coercive action, including arrest or custodial interrogation, until the strike was over and the courts resumed.A Vacation Bench of Justices Indira Banerjee and Sanjiv Khanna on Monday had asked Mr. Kumar’s lawyer to approach the Registry for urgent listing as the seven days’ grace would be over on May 24. Besides, the Vacation Bench had said his plea could be heard only by a three-judge Bench.Now, with his plea not likely to come up this week, Mr. Kumar is in a quandary.On May 17, a three-judge Bench led by Chief Justice Ranjan Gogoi had withdrawn a four-month-old order staying any attempt at coercive action, including arrest, against Mr. Kumar. The February 5 stay order asked the CBI to stand down while directing Mr. Kumar to travel to Shillong and co-operate with the agency.However, the acrimony between Mr. Kumar and the CBI had soured the questioning session, with the agency informing the court that the police officer met their questions with “silence and arrogance”.In an eight-page order on May 17, authored by Justice Khanna, the court had decided not to protect Mr. Kumar any longer. It had further left it open to the CBI to “act in accordance with the law”. However, the court gave him seven days from May 17 to approach a competent court and seek suitable legal relief like anticipatory bail.The CBI claims to have “substantial material” implicating Mr. Kumar in acts of connivance and complicity to favour the principal accused persons in the Saradha scam.last_img read more

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After 12-Year Limbo, New GM Maize May Hit Europe’s Fields

first_imgBRUSSELS—In 2001, the agriculture giant now called DuPont Pioneer asked for approval to grow a new genetically modified (GM) maize variety in the European Union’s fields. Twelve years later, the company still doesn’t have an answer. Sharp divisions within the European Union, leading to a paralyzing indecisiveness, have kept the crop in limbo.Now, the European Commission has finally made a choice. Yesterday, it proposed to allow cultivation of maize 1507, as the variety is known. It would be only the third GM crop allowed for cultivation in the European Union, where consumers and many national governments have strong reservations about genetically engineered food.The commission also pressed member states to avoid these lengthy deadlocks in the future by reconsidering a 3-year-old proposal to reform the union’s GM authorization procedures. As far as the commission is concerned, individual member states could decide to restrict a given crop on their territory in the future—even if the European Union’s food safety watchdog says there is no reason to block them.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Maize 1507 is engineered to produce its own insecticide against the European corn borer, a moth whose caterpillars chew on corn ears and stalks. Environmental groups oppose the crop’s introduction; they worry that maize 1507 will harm nontarget species and lead to a surge in the use of a toxic herbicide to which maize 1507 has been made resistant. The European Food Safety Authority (EFSA) has given the variety a green light in six reports since 2005, albeit with some restrictions to prevent collateral damage, such as planting 20% of conventional corn as a “buffer zone” around a GM field. “It is clear that the scientific evidence supports approval for cultivation of this crop,” writes Anne Glover, the commission’s chief scientific adviser, in an e-mail to ScienceInsider.But EFSA does not have the final word. Based on its advice, the European Commission issued a draft decision to authorize the crop. Member states had to sign off on that decision through a regulatory committee, made up of experts from each government. The committee failed to reach a consensus, however: E.U. countries such as Austria and France are strictly opposed to growing GM crops, while other states, including Spain and the Netherlands, are more GM-friendly.Instead of referring the matter to the higher level—the Council of Ministers—the commission then sat on the file for several years. Pioneer fought that inaction in court. In September, the Court of Justice of the European Union in Luxembourg finally slammed the commission’s failure to reach a timely decision, and now, the commission is pressuring member states to decide. If the Council of Ministers does not muster a weighted majority to reject the crop’s cultivation within 3 months, the European Commission has the right to authorize it anyway—and it says it will do so.What’s more, health commissioner Tonio Borg has urged ministers to get their act together so that other crops won’t suffer similar delays. Borg told reporters here yesterday that he wants to revive the commission’s so-called “cultivation proposal,” put forward in 2010 to reform authorization procedures. Under this plan, a green light from the European Commission would remain valid across the European Union by default, but member states could individually decide not to grow an authorized GM crop on their territory—even if EFSA sees no scientific objections.That proposal—an agreement to disagree—hasn’t gone anywhere either, however. According to sources close to the negotiations at the time, France, Germany, and the United Kingdom opposed the idea of letting countries make individual decisions. Some doubted the legal validity of the plan. Others disagreed with the very idea of “renationalizing” procedures that should be valid across the European Union; they argued that the commission was passing the hot potato back to the member states, which are under pressure from consumers who often reject GM food. Instead of trying to build coherent E.U.-wide rules, the commission “is shying away now that the going gets tough,” says Angelika Hilbeck, an agroecology researcher at the Swiss Federal Institute of Technology in Zurich.At the moment, only two GM crops are allowed for cultivation in the European Union, and only one is actually grown: Monsanto’s MON810 maize, approved in 1998, which represents 1.35% of the total surface of maize planted in the union, most of it in Spain. Fifty-one GM crops are authorized for importation in the European Union, in particular soya and maize for feed use.A spokesman for Pioneer Europe in Manno, Switzerland, says the company is now “confident” that maize 1507 will be approved for cultivation “without further delay.” But environmental groups still hope its introduction can be stopped. “We don’t need to take risks with untested and toxic GM crops that threaten our environment and lead to more industrial farming,” said Mute Schimpf, a food campaigner for Friends of the Earth Europe, in a statement on 5 November.last_img read more

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Japan’s Latest Stem Cell Apology

first_imgNobel Prize winner Shinya Yamanaka today joined a growing crowd of Japanese stem cell scientists who have held press conferences in recent weeks to apologize for mistakes in published papers. Yamanaka discovered in 2006 a way to reprogram adult cells into embryolike ones, called induced pluripotent stem (iPS) cells, a find that has revolutionized the stem cell field. He was honored in 2012 with the Nobel Prize in physiology or medicine and is one of Japan’s most famous researchers. The iPS cell research is not in question, but a frenzy of anonymous bloggers searching for flaws in prominent researchers’ papers did find fault with one of his older publications.At a press conference today, he said that a paper published in 2000 contains an image that may be incorrect. Anonymous online posts first raised questions about the image, and Kyoto University has investigated the paper at Yamanaka’s request, The Wall Street Journal reports. The university found no problems with the paper’s conclusions, but Yamanaka says he no longer has the records needed to verify the image, because the experiment was done by collaborators. He said he will take it as a lesson on the importance of taking and preserving “proper notes that can be presented at any time.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Apparently fighting back tears (video in Japanese), Yamanaka told the press conference, “Under recent circumstances, when confidence in the trustworthiness of Japan’s research has been shaken, this kind of announcement must be made. I apologize from the bottom of my heart.”  He then stood and made a ritual bow of apology.Yamanaka was referring to a recent string of public apologies by stem cell scientists in Japan, triggered by two high-profile papers published earlier this year that claim to have found an alternate way to reprogram adult cells into embryolike ones—called STAP (stimulus-triggered acquisition of pluripotency) cells. Other labs have not been able to replicate that work, and an investigating committee found evidence of misconduct by lead author Haruko Obokata. The leaders of the RIKEN institute where Obokata works, several of Obokata’s co-authors, and Obokata herself have all publicly apologized for the mistakes and the confusion they have caused. Last week, the saga took a new twist when the chair of the investigating committee, Shunsuke Ishii, resigned after evidence surfaced of problems in publications he had co-authored. (An investigation is ongoing.) He apologized as well.Yamanaka was not involved in the STAP cell research. His reprogramming methods were quickly replicated by other scientists and are now widely used around the world.With reporting by Dennis Normile.last_img read more

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Young Blood Renews Old Mice

first_imgCould the elixir of youth be as simple as a protein found in young blood? In recent years, researchers studying mice found that giving old animals blood from young ones can reverse some signs of aging, and last year one team identified a growth factor in the blood that they think is partly responsible for the antiaging effect on a specific tissue—the heart. Now, that group has shown this same factor can also rejuvenate muscle and the brain.”This is the first demonstration of a rejuvenation factor” that is naturally produced, declines with age, and reverses aging in multiple tissues, says Harvard University stem cell researcher Amy Wagers, who led efforts to isolate and study the protein. Independently, another team has found that simply injecting plasma from young mice into old mice can boost learning.The results build on a wave of studies in the last decade in which investigators sewed together the skins of two mice, joining their circulation systems, and studied the effects on various tissues. “It’s still a bit creepy for many people. At meetings, people talk about vampires,” says neuroscientist Tony Wyss-Coray of Stanford University in California, who led one of the brain studies. But he, Wagers, and others think unease will give way to excitement. The new work, he says, “opens the possibility that we can try to isolate additional factors” from blood, “and they have effects on the whole body.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Hope and hype are high in the antiaging research arena, and other researchers caution that the work is preliminary. “These are exciting papers,” but “it’s a starting point,” says neuroscientist Sally Temple of the Neural Stem Cell Institute in Rensselaer, New York. Adds Matt Kaeberlein, a biologist who studies aging at the University of Washington, Seattle, “The therapeutic implications are profound if this mechanism holds true in people.” But that “is the million-dollar question here, and that may take some time to figure out.”The experimental technique of joining mice’s circulatory systems dates back 150 years. Around 2000, then-postdoc Wagers and other researchers in Irving Weissman’s and Thomas Rando’s labs at Stanford revived the method, known as parabiosis, to study the fate of blood stem cells and muscle cells. To their surprise, they found that when old and young mice were joined, the muscle stem cells in old mice were revitalized. Since then, Stanford researchers and others, including Wagers, have published about a half-dozen papers showing that old-young parabiosis can also improve the health of an aging mouse’s liver, spinal cord, and brain.More recently, Wagers’s lab, together with cardiologist Richard Lee’s lab at Brigham and Women’s Hospital in Boston, isolated a specific protein from mouse blood that they think can explain some of the effects. The protein, growth differentiation factor 11 (GDF11), was known to regulate stem cell activity; it is abundant in young mice but its level drops as the animals age. Last year in Cell, Wagers’s and Lee’s labs reported that injections of GDF11 can reduce the thickening of the heart that typically comes with aging in mice. Today, in a paper in Science Express, Wagers’s lab shows that GDF11 works nearly as well as parabiosis in helping aging mice recover from a muscle injury and boosts their performance on running and grip strength tests.In another study of mice injected with GDF11, postdoc Lida Katsimpardi and others in the lab of Harvard neuroscientist Lee Rubin found that GDF11 also encourages growth of new blood vessels and olfactory neurons in the mouse brain. As they report in a second Science Express paper today, the animals gained a keener sense of smell. In both muscle and the brain, GDF11 appears to work in part by restoring the function of stem cells.So far only two other interventions—the drug rapamycin and caloric restriction—have been shown convincingly to slow or reverse aging in multiple tissues, Kaeberlein says. Wagers points out that GDF11 could be safer than a drug because it’s found naturally in blood. Harvard has filed for patents on GDF11, and Wagers says she and her colleagues are “in the process of talking with people” about commercializing it to treat diseases such as Alzheimer’s and heart disease. Giving GDF11 itself “would require huge amounts of protein,” Wagers says, so it may be better to use a modified form or to target the GDF11 pathway with a different molecule. “These are tractable problems,” Wagers says. “The most important hurdle was figuring out a pathway to go after.”Temple agrees that GDF11 has therapeutic promise, but she says she will remain cautious until more is known about GDF11’s mechanism. She also notes that some of the “old” mice in the Harvard brain studies were only middle-aged, and whether the effects would hold up in elderly people is unclear. “It’s a matter of where you can step in,” she says. Nor have any studies yet shown that the treated mice live longer.Already, GDF11 has a potential rival treatment. In Nature Medicine today, Wyss-Coray’s lab at Stanford and Saul Villeda and co-workers at the University of California, San Francisco, report that parabiosis can rejuvenate another part of the mouse brain, the hippocampus, where memories are made and stored. Old mice that underwent parabiosis formed more new connections between nerve cells there. Although Wyss-Coray’s group has not yet isolated any rejuvenation factors from the young blood, they have found what might be an alternative. When Wyss-Coray’s team tried a simpler experiment than parabiosis—giving old mice injections of plasma from young mice—they saw similar effects on the hippocampal neurons. The old mice also performed significantly better than untreated animals on tests of learning and memory.Plasma is given routinely to patients, so trials of this approach, unlike those testing a new protein, would not require U.S. Food and Drug Administration approval, Wyss-Coray says. His group has started a company that is planning a small clinical trial that would give Alzheimer’s patients a series of injections of plasma from young donors. In mouse models of Alzheimer’s, they have already seen positive effects, he says.Let a new wave of hope—and hype—begin.View our related Science in the Classroom annotated research paper on rejuvenation of the aging mouse brain.last_img read more

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