In August, Pearl Jam hit Chicago’s Wrigley Field, as the band continued their brief U.S. run of “Home” and “Away” shows, which kicked off with a pair of performances in their native Seattle, Washington. The sold-out show saw the band performing many of their classic tracks in addition to tributes to Tom Petty (“I Won’t Back Down”), David Bowie (“Rebel, Rebel”), and Chris Cornell (“Missing”). Hilariously though, what the show will likely be remembered for is the appearance of Dennis Rodman during the show’s first of two encores.After the encore-opening rendition of “Just Breathe”, the former NBA superstar and five-time NBA champion appeared on stage to give Pearl Jam’s frontman Eddie Vedder a ukelele before his song “Sleeping By Myself”. Rodman, as of late, has become well-known for his close relationship with North Korea, having visited North Korea’s capital, Pyongyang, multiple times and serving as a truly bizarre ambassador between the United States and the isolationist country led by dictator and major basketball fan Kim Jong-un.While the appearance of Dennis Rodman was no doubt surprising to many, it’s not necessarily totally out-of-left-field. Rodman has gone on the record as a major fan of the iconic rock act, having made guest cameos at several of their concerts over the years. Rodman also publicly thanked Eddie Vedder on television earlier in 2018 while he was on hand in Singapore for Donald Trump’s North Korea Summit. As he explained in an interview last year, “I went and got that album [Ten] and I would played it every day. For some reason, [“Black”] was on, I think that saved my life.”Watch pro-shot video of Pearl Jam covering David Bowie’s “Rebel, Rebel” below:Pearl Jam – “Rebel, Rebel”[Video: Pearl Jam][H/T Jambase]
In recent years investigators have discovered that breast tumors are influenced by more than just the cancer cells within them. A variety of noncancerous cells, which in many cases constitute the majority of the tumor mass, form what is known as the “tumor microenvironment.” This sea of noncancerous cells and the products they deposit appear to play key roles in tumor pathogenesis.Among the key accomplices in the tumor microenvironment are mesenchymal stem cells (MSCs), a group of adult progenitor cells, which have been shown to help breast cancers maneuver and spread to other parts of the body.Now, new research sheds further light on how this spreading is happening. Led by investigators at Harvard-affiliated Beth Israel Deaconess Medical Center (BIDMC), the research demonstrates that the lysyl oxidase (LOX) gene is spurred to production in cancer cells as a result of their contact with MSCs, and once produced, can help ensure the spread of otherwise weakly metastatic cancer cells from primary tumors to the lung and bones. Described online in the Proceedings of the National Academy of Sciences (PNAS), this discovery not only provides key insights into the basic biology of tumor formation, but also offers a potential new direction in the pursuit of therapies for the treatment of bone metastasis.“We don’t have a lot of therapies that can target breast cancer once it has metastasized, particularly once cancer cells have lodged in the bone,” says senior author Antoine Karnoub, an investigator in the Department of Pathology at BIDMC and assistant professor of pathology at Harvard Medical School. “When breast cancer cells reach the skeleton, one way in which they cause damage is by breaking down bone tissue, which results in the bone’s rich matrix releasing numerous factors. These factors, in turn, feed the cancer cells, setting in motion a vicious cycle that leaves patients susceptible to fractures, pain, and further metastasis.”MSCs are nonhematopoietic progenitor cells predominantly produced in the bone marrow that generate bone, cartilage, fat, and fibrous connective tissue. They additionally support immune cell development and are recruited to inflammatory sites throughout the body to help shut down immune responses and regenerate damaged tissues, as might occur during wound healing. Several years ago, as a postdoctoral researcher at the Whitehead Institute of the Massachusetts Institute of Technology, Karnoub began exploring the idea that MSCs were migrating to tumors after mistaking the cancer sites for inflammatory lesions in need of healing.“We discovered that once MSCs had reached the tumor sites, they were actually helping in cancer metastasis, causing primary cancer cells to spread to other sites in the body,” he explains. In this new research, Karnoub wanted to find out — in greater molecular detail — how breast cancer cells respond to the influences of MSCs in order to better understand how cancer cells cross talk with recruited cells in the microenvironment.His scientific team first embarked on a straightforward experiment. “We took two dishes of cells, cancer cells and MSCs, and mixed them together,” Karnoub explains. After three days, the researchers removed the cancer cells and studied them to see how they had changed.“We found that the lysyl oxidase gene was highly upregulated in the cancer cells,” Karnoub says. “It turns out that when a cancer cell comes in contact with an MSC, it flips on this LOX gene, turning it up by a factor of about 100. So our next question was: What happens to the cancer cells when they encounter this boost of LOX that they themselves have produced?”The answer, as revealed in subsequent experiments, was that LOX was setting in motion a cell program called epithelial-to-mesenchymal transition (EMT). During EMT, cancer cells that usually clump together undergo a transformation into cells that exhibit decreased adhesion to their neighbors and go their own way. As a result, these cancerous cells are able to migrate, significantly enhancing their ability to metastasize.“When we put these cells back into mice, they not only formed tumors that metastasized to the lung, but also to the bone,” says Karnoub. “This makes you wonder whether the cancer cells in primary tumors have become so acclimated to interacting with bone-derived MSCs that they can now grow more easily in the bone once they leave the tumor.”The investigators also wanted to find out if, by going through the EMT process, cancer cells were also acquiring the phenotypes of another highly aggressive feature of malignant cancer cells, those of cancer stem cells within the cores of most tumors.“Cancer stem cells are believed to be responsible for the resurgence of tumors following chemotherapy treatment, and an increasing body of science is focused on understanding how CSCs function and how they originate,” says Karnoub. “The processes of EMT and CSC formation have been described as being closely coupled, and we asked whether LOX might be regulating CSC phenotypes, just as it was regulating EMT. To our surprise, this was not the case. This tells us that pathways that were once thought to be intimately intertwined and commonly tweaked may, in fact, be separate, and now we can start to tease out the respective circuitries with a bit more clarity.”Lastly, the investigators identified the mechanism that was enabling LOX to be turned on from outside the cell, a set of molecules called hyaluronic acid (HA) and CD44. “It turns out that the MSCs provide the HA while the cancer cells provide the CD44, and they work in tandem like a lock and key to upregulate LOX expression,” explains Karnoub, adding that antagonists to HA and CD44, already in extensive investigations and clinical exploration, might be of increased use from a clinical standpoint, perhaps in managing bone metastasis.To read the full story.
Emong (left) won the sprint finish to win gold at the World Championships in London.Kampala, Uganda | THE INDEPENDENT | Para-Athlete David Emong, rugby star Phillip Wokorach, football ace Geoffrey Sserunkuma and queen of the netball court Peace Proscovia will vie for the Uganda Sportsperson of the Year 2017 accolade. The Nile Special awards winner will be announced at the annual Uganda Sports Press Association (USPA) gala at a later date.The four stars were nominated by the Uganda Sports Press Association at their monthly assembly in Kampala on Monday at Imperial Royale Hotel. The journalists also voted the best in various sports categories.Emong was nominated for his feat after winning the country’s first Paralympic gold medal while Sserunkuma got on the list for leading the goal scoring charts for champions KCCA on the local and continental level.Proscovia led the She Cranes to Africa glory, having grabbed 130 of 270 goals the team scored on their way to the title in Kampala.Wokorach helped Uganda defend the Africa Sevens title as Uganda qualified for the 2018 World Cup Sevens.Emong was a runner-up for the Uganda sportsman of the year 2016 title that was awarded to footballer Denis Onyango. KickboxerNile Special USPA Kickboxer of 2017-Patricia ApolotLudoNile Special USPA Ludo player of 2017 –Kato CharlesSwimmingNile Special USPA Female Swimmer of 2017-Avice Meya* USPA Male Swimmer of 2017- Tendo Mukalazi HockeyNile Special USPA Male Hockey player of 2017- Emmanuel BagumaNile Special USPA Female Hockey player of 2017- Doreen MbabaziTennisNile Special USPA Tennis player of 2017- Duncan MugabeBody buildingNile Special USPA bodybuilder of 2017-Isaac MubikirwaSquashNile Special USPA squash player of 2017- Michael Kawooya*-MinorsMale Badminton player of the year- Brian Kasirye 16 yearsFemale Badminton player of the year-Husnah Kobugabe 17 yearsMotocross rider of the year- Isabella Blick 9 yearsFemale athlete of the year-Josephine Lalam 17 years.Male swimmer of the year-Tendo Mukalazi 15 years. Nile Special USPA Footballer of 2017 is Sserunkuma, the Male Athlete of 2017 is Emong, the Male rugby player of 2017 is Phillip Wokorach while Netballer of 2017 is Peace Proscovia.Here is list of all the nominees and winners.Nile Special USPA Sports Personality of the year nomineesDavid EmongPhillip WokorachGeoffrey SserunkumaPeace Proscovia Nile Special USPA team of the year nomineesCity OilersNational Rugby 7s teamLady Cricket CranesShe CranesKCCA FC Nile Special USPA best organized event of the year nominees-FIBA Zone 5 Club Championships-Africa Rugby 7s Championships-Uganda Golf Open-IAAF World Cross Championships Athletics* USPA Female Athlete of 2017 –Josephine LalamNile Special USPA Male Athlete of 2017- David Emong BoxingNile Special USPA Boxer of 2017 – Muzamir Kakande FootballNile Special USPA Footballer of 2017- Geoffrey SserunkumaNile Special USPA Female Footballer of 2017-Vanessa Edith Karungi MotorsportNile Special USPA Rally Crew of 2017- Christakis Fitidis and Eric Nzamwita GolfNile Special USPA Male golfer of 2017- Ronald RugumayoNile Special USPA Female golfer of 2017- Martha Babirye CricketNile Special USPA Male cricketer of 2017- Kenneth WaisswaNile Special USPA Female cricketer of 2017- Gertrude Chandiru PoolNile Special USPA Male Pool player of 2017- Fahad SsewankamboNile Special USPA Female Pool player of 2017- Victoria Namuyanja Badminton* USPA Male Badminton player of 2017- Brian Kasirye* USPA Female Badminton player of 2017- Husnah Kobugabe KarateNile Special USPA Male Karateka of 2017- Ronald MwanjeNile Special USPA Female Karateka of 2017- Linda Ochen Share on: WhatsApp Table Tennis ?Nile Special USPA Male T/Tennis player of 2017-Nile Special USPA Female T/Tennis player 2017- Woodball ?Nile Special USPA Female Woodball player of 2017-Nile Special USPA Male Woodball player of 2017- WeightliftingNile Special USPA weightlifter of 2017- Hakim SsemperezaRugbyNile Special USPA Female rugby player of 2017- Samiya AyikoruNile Special USPA Male rugby player of 2017- Phillip WokorachBasketballNile Special USPA Male Basketballer of 2017- Jimmy EnabuNile Special USPA Female Basketballer of 2017-Vilma AchenMotocross* USPA Motocross rider of 2017- Isabella BlickChessNile Special USPA Male Chess player of 2017- Patrick KawumaNile Special USPA Female Chess player of 2017- Maria NakanyikeVolleyballNile Special USPA Female Volleyballer of 2017- Margaret NamyaloNile Special USPA Male Volleyballer of 2017- George AporuNetballNile Special USPA Netballer of 2017-Peace Proscovia
Facebook0Tweet0Pin0 Submitted by the Timberland Regional LibraryOlympia resident Dee Williams hand-crafted her beautiful 84 square foot house and wrote a book about the experience, “The Big Tiny: A Built-It-Myself-Memoir.” She will speak at the Olympia Timberland Library on Thursday, July 31 from 7:30 to 8:45 p.m.In building her tiny home, Williams discovered that the important stuff in life isn’t stuff.“Admitting that I’m “happy enough” makes me wonder if I’m falling short of my potential as a middle-class American,” Williams writes on her website. “But the facts are the facts,” she continues, “I found a certain bigness in my little house – a sense of largeness, freedom, and happiness that comes when you see there’s no place else you’d rather be.”Jim Lynch, author of “The Highest Tide,” writes: “The Big Tiny” is irresistible. Dee Williams is as much fun on the page as she is in person. Comic, silly, and soulful, she takes us on her journey to simplify her life and along the way tunes in to our own inner desire to pare down to our nearly naked selves.”Williams founded Portland Alternative Dwellings (PAD) to help others find a way to make their housing serve their lives. She has been featured in The New York Times, Los Angeles Times, Yahoo.com, National Public Radio, CBS This Morning and more.Attendees may bring their own copies of the book to be signed. Books will also be available for purchase. Learn more about Dee and the tiny house movement at www.padtinyhouses.com.This program will take place after regular library hours and no other services will be available.The Olympia Timberland Library is located at 313 8th Ave.SE. For more information contact the library at (360) 352-0595 or visit www.TRL.org